All you need to know about Iron Infusion

In-Home Care

nurse next door logo By Nurse Next Door April 21, 2025

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This article is written by Nurse Next Door

Do you know iron deficiency anemia is common among seniors? Normal iron levels in the body are very crucial for proper hemoglobin production and oxygen transport. Low levels of iron can make you feel tired and dizzy and even cause other health complications. Some people are unable to tolerate or absorb oral supplements of iron. In such cases, iron infusion is very effective. This article includes a comprehensive guide related to iron infusion, its indications, benefits, side effects, and all other details that one needs to know. 

What is Iron Infusion? 

Iron infusion therapy is an intravenous procedure of delivering iron into the bloodstream for a rapid increase in its level. This method allows iron to be delivered almost instantly. Therefore, it comes in handy when oral supplementation is no longer an option or preferred.

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Types of Iron Infusion Therapy

Here are the main types of iron infusions:

  • Iron Dextran: Effective for anemia but requires a test dose.
  • Iron Sucrose (Venofer): No test dose is needed and it’s well-tolerated. 
  • Ferric Carboxymaltose (Injectafer): Fast replenishment, two doses needed. 
  • Ferumoxytol (Feraheme): For chronic kidney disease-related anemia. 
  • Iron Isomaltoside (Monofer): Effective replenishment. 
  • Ferric Derisomaltose: Single treatment for large doses.

Indications for Iron Infusion 

Here are some of the prevalent conditions in which iron infusion is preferred over oral supplements:

  • Severe iron deficiency anemia: Infusion therapy is crucial when hemoglobin is dangerously low or rapid correction is required. Around 30% of the people worldwide suffer from iron deficiency anemia, particularly women and children.
  • Malabsorption conditions: In disorders like celiac or after gastric surgery, absorption of oral iron is poor. 
  • Chronic kidney disease and dialysis: Intravenous (IV) iron is used to maintain iron levels alongside ESA therapy.
  • Inflammatory bowel disease (IBD): Oral iron supplements may worsen GI symptoms. Therefore, IV iron is safer and more effective.
  • Pregnancy-related anemia: It’s recommended in situations where oral iron fails or causes intolerance. Anemia affects 40% of pregnant women globally.

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The Iron Infusion Procedure 

Preparation

Before starting the infusion therapy, your healthcare provider will conduct blood tests to assess the iron levels and overall health. On the day of the procedure, you can eat your regular meals and take prescribed medications as usual. Also, keeping yourself hydrated is important.

During the Infusion

The nurse inserts a catheter into a vein of your hand or arm. The catheter is connected to the iron solution via a long tube, and it helps administer iron into the body. The infusion usually takes between 15 to 30 minutes. During this time, the patient is monitored for any immediate reactions. Minor side effects like flushing or nausea may occur but are generally manageable.

Post-Infusion

For around 30 minutes after the infusion, a healthcare professional will observe you to ensure no adverse effects develop. One can continue their normal daily activities immediately, but avoiding strenuous exercise is advised.

Benefits of Iron Infusion

Here are some important benefits associated with iron infusion:

  • Rapid improvement in iron levels compared to oral supplements. Thus, providing faster symptom relief.
  • Alleviation of anemia symptoms, including fatigue, shortness of breath, and dizziness.
  • Improved quality of life and physical performance, with patients reporting more energy and stamina after the infusion.

Potential Side Effects and Risks Of Iron Infusion

Common Side Effects

  • Temporary changes in taste
  • Headaches
  • Nausea or vomiting
  • Muscle and joint pain
  • Itching or rash

Serious Risks

  • Allergic reactions, including anaphylaxis (rare)
  • Low blood pressure
  • Iron overload with repeated infusions

Comparing Iron Infusion to Other Iron Supplementation Methods

As iron deficiency anemia (IDA) affects 30% of the global population, effective treatment is essential.

Intravenous iron infusion is ideal for IDA due to rapid delivery to the bloodstream. But, besides this, here are some other iron supplementation methods: 

Oral Supplements

Oral supplements are an effective and affordable option that can be used in mild IDA cases. However, it can cause GI side effects like nausea and constipation. 

Intramuscular Injection

This option is relatively less preferred due to side effects like pain, skin discoloration, and the risk of muscle damage or abscess formation. 

Therefore, the choice of iron supplementation method depends on the severity of anemia, the patient’s tolerance, and clinical considerations.

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Iron Infusion During Pregnancy 

Maintaining normal iron levels in pregnancy is crucial. Otherwise, decreased iron levels can lead to anemia, which is associated with increased risks of hemorrhage, sepsis, and low birth weight. 

For this purpose, IV iron infusion is a safe and effective method and is administered during the second and third trimesters. This helps in improving maternal hemoglobin levels and reducing fatigue. Therefore, supporting better outcomes for both the mother and fetus.

Monitoring and Follow-Up Care 

  • Schedule blood tests 2 to 4 weeks post-infusion to assess iron levels. Your doctor will guide you about what iron levels require iron infusion and whether you need one or not. 
  • Watch for joint or muscle pain, fever, swelling, allergies or skin reactions.

 ​Explore Nurse Next Door’s In-Home IV Infusion Care Services 

Nurse Next Door provides comprehensive in-home IV infusion care, including post-infusion monitoring and support. Besides watching for signs of swelling or allergies, our Registered Nurses (RNs) take all precautionary measures such as removing air from the IV line. We also ensure the needles and other medical waste are disposed of properly. With this approach, you or your loved one can recover safely and comfortably at home. We connect our clients with the most suitable RNs, who are trained, experienced, and licensed by the Virginia Board of Nursing. Reach out to us today to learn more about iron infusion cost and other details.  

Conclusion

Taking oral iron supplements is not the right option for many individuals. Iron infusion therapy is effective in such cases. It delivers high doses of iron in a short amount of time and helps you avoid some of the side effects associated with oral iron supplements. Contact Nurse Next Door now to overcome anemia and maintain healthy iron levels.​